Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers
Identifieur interne : 001454 ( Main/Exploration ); précédent : 001453; suivant : 001455Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers
Auteurs : Atsushi Sasaki [États-Unis] ; Steven W. Levison [États-Unis] ; Jenny P.-Y. Ting [États-Unis]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1990.
English descriptors
- Teeft :
- Acad, Ameboid, Ameboid microglia, Antigen expression, Antigen presentation, Astrocyte, Astroglia, Astroglial, Astroglial cultures, Brain cells, Calmodulin antagonist, Cell type, Chapel hill, Cultured astrocytes, Cultured astroglia, Cyclic nucleotide, Dbcamp, Encephalomyelitis, Endothelial cells, First treatment, Flow cytometry, Forskolin, Frohman, Glial cells, Immune response, Immune responses, Immunol, Increase intracellular camp, Interferon receptors, Intracellular, Intracellular camp, Jenny ting, Kinase, Large number, Macrophage, Major histocompatibility, Microglia, Monoclonal antibodies, Multiple sclerosis lesions, Natl, Negative control, Neuroimmunol, Other substances, Positive regulator, Previous report, Primary astroglial cultures, Proc, Protein kinase, Reagent, Receptor, Sasaki, Second messengers, Secondary messengers, Separate experiments, Simultaneous treatment, Suppressive effect, Various concentrations.
Abstract
Abstract: The roles of intracellular second messengers in interferon-γ (IFN-γ)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-γ. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-γ-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-γ-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia+ microglia (or macrophages) but not astroglia in various neurodegenerative diseases.
Url:
DOI: 10.1016/0165-5728(90)90164-I
Affiliations:
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Le document en format XML
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Ia Ag on both glia types was induced by IFN-γ. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-γ-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-γ-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia+ microglia (or macrophages) but not astroglia in various neurodegenerative diseases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Sasaki, Atsushi" sort="Sasaki, Atsushi" uniqKey="Sasaki A" first="Atsushi" last="Sasaki">Atsushi Sasaki</name></noRegion><name sortKey="Levison, Steven W" sort="Levison, Steven W" uniqKey="Levison S" first="Steven W." last="Levison">Steven W. Levison</name><name sortKey="Ting, Jenny P Y" sort="Ting, Jenny P Y" uniqKey="Ting J" first="Jenny P.-Y." last="Ting">Jenny P.-Y. Ting</name><name sortKey="Ting, Jenny P Y" sort="Ting, Jenny P Y" uniqKey="Ting J" first="Jenny P.-Y." last="Ting">Jenny P.-Y. Ting</name><name sortKey="Ting, Jenny P Y" sort="Ting, Jenny P Y" uniqKey="Ting J" first="Jenny P.-Y." last="Ting">Jenny P.-Y. 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